AS and AS Genotype Marriage: Healthy childbearing options

You just found out that you and your partner both have the AS genotype, can you still get married and have healthy kids? Read this article to find out-

AS and AS genotype marriage

As opposed to popular opinion that AS and AS genotype couples should never marry as it is impossible for them to predict the genotype of their child, medical advancements have made it possible for that to become a thing of the past. 

AS and AS genotype couples can now safely marry and give birth to all AA genotype kids if they want.

It is important to note that some of these processes are quite expensive and unaffordable for some people. It could also be emotionally and physically draining both for the woman who gets to undergo a cycle of procedures and for the couple as a unit. 

This should be brought into consideration before venturing into an AS and AS genotype marriage.

But what if you and your partner are financially, physically and emotionally ready? What are the available procedures by which you can safely deliver healthy children?

Preimplantation genetic diagnosis (PGD) + In-vitro fertilisation (IVF)

Preimplantation genetic diagnosis (PGD) is a medical procedure usually carried out in a laboratory in conjunction with in vitro fertilisation with the aim of reducing the risk of passing on inheritable conditions. 

PGD + IVF can be used to prevent the passing on of common single-gene mutations such as sickle cell anaemia and cystic fibrosis. 

PGD works in conjunction with IVF, where multiple eggs are allowed to mature at once and retrieved. They are then fertilized with a single sperm cell each. The resulting fertilized eggs are grown in the lab up until the third day of development where they would be tested for sickle cell anemia. 

The fertilised eggs that do not have the sickle cell gene would then be transferred to the woman’s womb on the fifth day of development.


  • This process has close to 100 percent reliability and almost completely reduces the chances of giving birth to a child with the sickle cell genotype. 
  • It also makes it possible to select healthy embryos to be implanted in the future.
  • When compared with amniocentesis and chorionic villus sampling, it is highly advantageous as only healthy embryo will be implanted and there is no need for pregnancy termination at any point;


  • It is an expensive procedure. IVF costs in Nigeria could run up to about 1 million naira while the cost of PGD could be up to about 4 million naira.
  • IVF procedure could be painful and emotionally draining, the process of hormonal stimulation and egg retrieval could be painful for some women and if unsuccessful, having to repeat the procedure could take an emotional toll on the couple
  • As with many other medical procedures, PGD is not absolute and the risk of all fertilised embryos having the genetic disease still exists.


The amniotic sac contains amniotic fluid in which the unborn foetus grows during pregnancy. Amniocentesis is a medical procedure that is done whereby a thin needle is used to remove a small amount of amniotic fluid from the amniotic sac. 

This fluid is then tested in the laboratory to determine if the foetus has any genetic disease such as sickle cell anaemia. It is usually carried out between the 15th and 20th week of pregnancy.


  • It is cheaper when compared with PGD + IVF
  • Natural conception is carried out and there is no need for IVF


  • There is a greater risk of miscarriage
  • Uncertainty and emotional toll of having to abort the baby if found to have sickle cell anaemia.

Chorionic villus sampling (CVS)

CVS is performed earlier during pregnancy than amniocentesis. It is usually carried out between the 10th and 13th week of pregnancy. It involves taking a small part of the placenta from where it is attached to the wall of the uterus. 

After the samples are taken, they are tested in the laboratory and results are usually available between 7 to 10 days. 


  • Since it is carried out earlier in pregnancy than amniocentesis, termination of pregnancy in case of foetus with the genetic disease is safer
  • It is cheaper when compared to PCG + IVF
  • Natural conception is also carried out hence no need for IVF


  • The risks of miscarriage are greater than in amniocentesis
  • Uncertainty and emotional toll of having to abort the baby if found to have sickle cell anemia.

Other choices to explore:

AS and AS couples could also consider the option of adoption or having a loving marriage without kids. 

Even though conception through these medical procedures might be more challenging and expensive, it is worth it for AS and AS couples who choose to brave it together and hopefully raise healthy kids someday.


  1. May I simply just say what a comfort to uncover somebody that genuinely understands what theyre talking about over the internet. You definitely realize how to bring an issue to light and make it important. More people should read this and understand this side of your story. I was surprised you arent more popular because you most certainly possess the gift.

  2. Howdy, I believe your web site may be having internet browser compatibility issues.
    Whenever I take a look at your web site in Safari, it
    looks fine but when opening in Internet Explorer, it’s got some
    overlapping issues. I merely wanted to provide you with a
    quick heads up! Aside from that, fantastic site!

  3. Great post. I was checking constantly this blog and I’m impressed!
    Very useful info specially the last part 🙂 I care for such information a
    lot. I was seeking this certain information for a long time.

    Thank you and good luck.

  4. It’s a pity you don’t have a donate button! I’d definitely donate to this excellent blog!
    I suppose for now i’ll settle for book-marking and
    adding your RSS feed to my Google account. I look forward to
    brand new updates and will talk about this blog with my
    Facebook group. Chat soon!

  5. Attractive part of content. I just stumbled upon your web
    site and in accession capital to assert that I get in fact enjoyed account your blog
    posts. Any way I will be subscribing in your augment and
    even I success you get entry to consistently quickly.

  6. I all the time used to read piece of writing in news papers
    but now as I am a user of internet so from now I am using net for articles, thanks to web.

  7. A person necessarily help to make significantly articles I might state.
    This is the first time I frequented your website page and thus far?
    I surprised with the analysis you made to create this actual put up amazing.

    Magnificent job!

  8. hey there and thank you for your information – I’ve definitely picked up anything new from right
    here. I did however expertise some technical issues using this web site, since I experienced
    to reload the website many times previous to I could get it to load correctly.
    I had been wondering if your web hosting is OK? Not that I am complaining, but sluggish loading instances times will sometimes affect your placement in google
    and could damage your high-quality score if ads and marketing with Adwords.

    Anyway I am adding this RSS to my e-mail
    and can look out for much more of your respective intriguing content.
    Make sure you update this again soon.

  9. Its like you read my mind! You seem to know a lot about this,
    like you wrote the book in it or something. I think that you could do with some pics to drive the message home
    a little bit, but other than that, this is magnificent blog.

    A great read. I’ll definitely be back.

  10. It’s actually a nice and useful piece of info.
    I am happy that you just shared this helpful information with us.
    Please stay us up to date like this. Thank you for sharing.

  11. What i do not realize is in truth how you are now not actually a lot more well-appreciated than you might
    be right now. You are so intelligent. You understand therefore considerably in the
    case of this subject, produced me individually consider
    it from numerous numerous angles. Its like women and men don’t seem to be involved except it is one thing to do with Woman gaga!
    Your individual stuffs great. All the time
    care for it up!

  12. Hi! I know this is kind of off topic but I was
    wondering which blog platform are you using for this site?

    I’m getting sick and tired of WordPress because I’ve had problems with hackers and I’m
    looking at options for another platform. I would be fantastic if
    you could point me in the direction of a good platform.

  13. I feel that is among the most vital information for me.
    And i’m satisfied reading your article. However wanna observation on some normal issues, The website taste is wonderful, the
    articles is truly excellent : D. Just right process,

  14. Howdy! I could have sworn I’ve visited your blog before but after going through many of the posts I realized it’s new to me. Regardless, I’m certainly delighted I found it and I’ll be bookmarking it and checking back often!

  15. Hi, I do think this is an excellent site. I stumbledupon it 😉 I may return yet again since I saved as a favorite it. Money and freedom is the best way to change, may you be rich and continue to help other people.

  16. Whats up very nice site!! Man .. Excellent .. Amazing ..

    I will bookmark your web site and take the feeds also? I’m satisfied to seek out numerous helpful information right here
    within the post, we’d like develop extra strategies on this regard, thanks for sharing.
    . . . . .

  17. magnificent points altogether, you just gained a emblem new
    reader. What would you recommend in regards to your submit that you just made
    some days in the past? Any certain?

  18. Its like you read my mind! You appear to know a lot about this,
    like you wrote the book in it or something. I think that you can do with a few pics to drive the message home a little bit,
    but instead of that, this is great blog. An excellent read.
    I will definitely be back.

  19. You can definitely see your enthusiasm within the article you write.
    The world hopes for even more passionate writers such as you who are not afraid to say how
    they believe. All the time go after your heart.

  20. Link exchange is nothing else except it is only
    placing the other person’s webpage link on your page
    at appropriate place and other person will also do same in support of

  21. Usually I don’t read post on blogs, but I wish to say that
    this write-up very compelled me to take a look
    at and do so! Your writing taste has been amazed me. Thanks, very nice

  22. Hello! I know this is kinda off topic nevertheless I’d figured I’d ask.
    Would you be interested in trading links or maybe guest
    authoring a blog post or vice-versa? My blog addresses a lot of the same topics as yours and I believe we could greatly benefit from each other.
    If you’re interested feel free to send me an e-mail.
    I look forward to hearing from you! Wonderful blog by the way!

  23. Amazing blog! Is your theme custom made or did you download it from somewhere?
    A design like yours with a few simple tweeks would really make
    my blog stand out. Please let me know where you got your design. Bless you

  24. Thanks on your marvelous posting! I definitely enjoyed reading
    it, you could be a great author. I will be sure to bookmark your blog and may come back very soon. I want to encourage one to
    continue your great job, have a nice evening!

  25. You actually make it appear so easy along with your presentation however I find this
    matter to be actually one thing which I believe I’d by no means understand.
    It sort of feels too complex and extremely wide for me.

    I am looking forward on your subsequent put up, I’ll attempt to get the cling
    of it!

  26. I was pretty pleased to uncover this great site. I want to to thank you for your time for this particularly fantastic read!!
    I definitely savored every part of it and i also have you bookmarked to
    check out new information in your web site.

  27. Howdy! I know this is kind of off-topic but I had to ask.

    Does running a well-established blog like yours take a massive amount work?
    I’m completely new to running a blog but I do write in my journal every day.

    I’d like to start a blog so I will be able to share my own experience and feelings online.
    Please let me know if you have any ideas or tips
    for new aspiring bloggers. Thankyou!

  28. I have been exploring for a little for any high-quality articles or blog posts on this sort of house
    . Exploring in Yahoo I ultimately stumbled upon this site.
    Studying this info So i am glad to show that I’ve an incredibly good uncanny feeling I found out just what I needed.
    I so much for sure will make certain to do
    not omit this site and provides it a glance regularly.

    Высокоскоростной доступ в Интернет: до 1000 Мбит/с
    Скорость подключения к Интернету — еще один важный фактор для успеха вашего проекта. Наши VPS/VDS-серверы, адаптированные как под Windows, так и под Linux, обеспечивают доступ в Интернет со скоростью до 1000 Мбит/с, что гарантирует быструю загрузку веб-страниц и высокую производительность онлайн-приложений на обеих операционных системах.

  30. I think that is one of the such a lot vital information for me.

    And i’m glad reading your article. However want to statement on few common things, The site style is perfect, the articles
    is in point of fact excellent : D. Good activity, cheers